Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sanger Sequencing01:57

Sanger Sequencing

776.0K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
776.0K
DNA as a Genetic Template02:05

DNA as a Genetic Template

9.7K
9.7K
DNA as a Genetic Template02:05

DNA as a Genetic Template

28.3K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
28.3K
DNA Microarrays02:34

DNA Microarrays

21.5K
Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
21.5K
Nucleic Acid Structure01:25

Nucleic Acid Structure

9.7K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
9.7K
DNA Agarose Gel Electrophoresis02:35

DNA Agarose Gel Electrophoresis

116.5K
Agarose gel electrophoresis is a laboratory technique commonly used to separate DNA fragments by size. However, it can also be used to isolate and purify DNA fragments using a gel extraction protocol.
Gel extraction follows five major steps: running gel electrophoresis to separate fragments, isolating the individual bands, extracting DNA from those bands, and removing the dye and salts from the extracted mixture to obtain pure DNA.
In cloning experiments, both the insert and vector DNA...
116.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Euro-Asian hybrids of Echinococcus multilocularis from red foxes in northern and northeastern Poland result from secondary contact between long-isolated populations.

Scientific reports·2026
Same author

Influence of daily physical activity and Body Mass Index on the incidence and severity of injuries during hiking - retrospective analysis of a cross-sectional Questionnaire Survey.

Annals of agricultural and environmental medicine : AAEM·2025
Same author

Evaluation of Motor Control Through Functional Movement Patterns of the Lumbar Spine Among Elite Special Forces Operators: A Pilot Study.

Healthcare (Basel, Switzerland)·2025
Same author

Physiotherapy in Prehabilitation for Bariatric Surgery-Analysis of Its Impact on Functional Capacity and Original Predictive Models of Functional Status Outcome.

Journal of clinical medicine·2025
Same author

Cervical Infection as a Novel Risk Factor for Perineal Obstetrical Trauma: A Cross-Sectional Study.

Journal of clinical medicine·2025
Same author

The impact of short-term blood pressure variability on cognitive decline in Parkinson's disease patients without co-morbidities.

Journal of neural transmission (Vienna, Austria : 1996)·2025

Related Experiment Video

Updated: Mar 1, 2026

CD Spectroscopy to Study DNA-Protein Interactions
06:48

CD Spectroscopy to Study DNA-Protein Interactions

Published on: February 10, 2022

7.7K

Spectral-dynamic representation of DNA sequences.

Dorota Bielińska-Wąż1, Piotr Wąż2

  • 1Department of Radiological Informatics and Statistics, Medical University of Gdańsk, Tuwima 15, 80-210 Gdańsk, Poland.

Journal of Biomedical Informatics
|June 8, 2017
PubMed
Summary

This study introduces a novel DNA sequence analysis method using physics-inspired graphical representations. The B-spectrum technique transforms DNA into dynamic models, offering a promising new tool for bioinformatics research.

Keywords:
Alignment-free methodsDescriptorsMoments of inertiaSimilarity/dissimilarity analysis of DNA sequences

More Related Videos

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

21.3K
A Femtoliter Droplet Array for Massively Parallel Protein Synthesis from Single DNA Molecules
10:45

A Femtoliter Droplet Array for Massively Parallel Protein Synthesis from Single DNA Molecules

Published on: June 20, 2020

11.0K

Related Experiment Videos

Last Updated: Mar 1, 2026

CD Spectroscopy to Study DNA-Protein Interactions
06:48

CD Spectroscopy to Study DNA-Protein Interactions

Published on: February 10, 2022

7.7K
Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

21.3K
A Femtoliter Droplet Array for Massively Parallel Protein Synthesis from Single DNA Molecules
10:45

A Femtoliter Droplet Array for Massively Parallel Protein Synthesis from Single DNA Molecules

Published on: June 20, 2020

11.0K

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Traditional DNA sequence analysis methods face challenges in capturing complex sequence dynamics.
  • Developing novel bioinformatics approaches is crucial for advancing genomic research.

Purpose of the Study:

  • To introduce a new method for representing and analyzing DNA sequences using principles from physics.
  • To establish a dynamic representation of DNA sequences for enhanced bioinformatics analysis.

Main Methods:

  • Formulated a graphical representation of DNA sequences using a B-spectrum, derived from spectroscopy and dynamics.
  • Transformed the B-spectrum into a rigid body model with material points for dynamic representation.
  • Utilized the ratio of centers of mass to moments of inertia as descriptors for DNA sequences.

Main Results:

  • The B-spectrum method provides a dynamic representation of DNA sequences.
  • Descriptors derived from the dynamic models effectively characterize DNA sequences.
  • Demonstrated strong performance on standard bioinformatics datasets, specifically first exons of β-globin genes.

Conclusions:

  • The B-spectrum approach offers a powerful and effective new method for DNA sequence analysis in bioinformatics.
  • This physics-based methodology shows significant potential for future genomic research and applications.