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Prognostic value of Ki-67 expression in patients with extensive-stage small cell lung cancer
Renguang Pei1, Liqin Zhang2, Chao Xie2
1Department of Interventional Therapy, Yijishan Hospital of Wannan Medical College, Wuhu, P.R. China.
Aim:
To determine whether Ki-67 has prognostic significance in patients with extensive-stage small cell lung cancer.
Patients & Methods:
A retrospective review identified 159 consecutive patients with extensive-stage small cell lung cancer. Ki-67 expression level at the time of diagnosis was retrieved. Survival was assessed by Kaplan-Meier method and long-rank test.
Results:
None of the clinical characteristics, including age, gender and lactate dehydrogenase, were significantly associated with Ki-67 expression level (p > 0.05). Patients with high Ki-67 expression had longer survival than patients with low Ki-67 expression (p = 0.078). Age, gender and lactate dehydrogenase were not significantly associated with survival (p > 0.05).
Conclusion:
Ki-67 expression level failed to have a markedly significant impact on survival in patients with extensive-stage small cell lung cancer.
