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Updated: Mar 1, 2026
11:15
Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
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An update on genomic-guided therapies for pediatric solid tumors
Pui Chi Tsui1, Yin-Fai Lee2, Zoey Wing Yee Liu3
1Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Future Oncology (London, England)
|June 8, 2017
Summary
Pediatric solid tumors have limited targeted therapy options. Reviewing genomic aberrations in common childhood cancers can guide precision medicine development and identify potential drug targets for future research.
Area of Science:
- Oncology
- Genomics
- Pediatric Medicine
Background:
- Limited FDA-approved targeted therapies exist for pediatric cancers compared to adult treatments.
- Genomic-based clinical trials for pediatric solid tumors are scarce, hindering precision medicine advancements.
- Genomic data in pediatric solid tumors is crucial for developing targeted treatment strategies.
Purpose of the Study:
- To review reported genomic aberrations in the eight most common pediatric solid tumors.
- To identify potential druggable targets within these pediatric solid tumors.
- To facilitate preclinical and clinical research for precision medicine in pediatric oncology.
Main Methods:
- Comprehensive literature review of genomic aberrations in pediatric solid tumors.
- Analysis of whole-exome sequencing (WES) and whole-genome sequencing (WGS) data from public databases (cBioPortal, PCGP, TARGET).
- Inclusion of data from non-WES/WGS studies to ensure a broad overview.
Main Results:
- Compilation of reported genomic aberrations across eight common pediatric solid tumors.
- Identification of specific genetic alterations with potential therapeutic implications.
- Highlighting of druggable events amenable to targeted therapies.
Conclusions:
- Genomic profiling of pediatric solid tumors reveals numerous aberrations.
- Targeted therapies based on identified genomic events hold promise for pediatric cancer treatment.
- Further research is needed to translate genomic findings into effective clinical applications for children.
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