Controlled ROS production by corannulene: the vehicle makes a difference
Limei Zhang1, Xiaopeng Dong, Di Lu
1School of Pharmaceutical Science & Technology, Tianjin Key Laboratory for Modern Drug Delivery & High Efficiency, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin 300072, China. zhaoyj@tju.edu.cn wangzheng2006@tju.edu.cn.
Biomaterials Science
|June 8, 2017
Summary
Curved corannulene (Cor) generates reactive oxygen species (ROS) but requires solubilization. Cyclodextrin complexation is more effective than PEGylation for enhancing ROS production in aqueous environments.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Curved corannulene (Cor) possesses a large dipole moment, enabling controlled reactive oxygen species (ROS) generation.
- Poor aqueous solubility of Cor limits its application, necessitating effective solubilization strategies.
Purpose of the Study:
- To compare the efficacy of PEGylation and cyclodextrin complexation for solubilizing curved corannulene.
- To evaluate the impact of these solubilization methods on ROS production.
Main Methods:
- Synthesis and characterization of PEGylated corannulene.
- Formation and characterization of corannulene-cyclodextrin complexes.
- Quantification of ROS production using spectroscopic methods.
Main Results:
- Cyclodextrin complexation significantly improved the aqueous solubility of Cor compared to PEGylation.
- Cor-cyclodextrin complexes exhibited enhanced and more controllable ROS production than PEGylated Cor.
- PEGylation showed limited efficiency in improving both solubility and ROS generation.
Conclusions:
- Cyclodextrin complexation is a superior strategy for enhancing the aqueous performance of curved corannulene for ROS generation.
- This finding has implications for developing advanced nanomaterials for applications requiring controlled ROS production.
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