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Open-source, community-driven microfluidics with Metafluidics.

David S Kong1, Todd A Thorsen1, Jonathan Babb2

  • 1Massachusetts Institute of Technology Lincoln Laboratory, Lexington, Massachusetts, USA.

Nature Biotechnology
|June 8, 2017
PubMed
Summary
This summary is machine-generated.

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Metafluidics is an open-source repository for microfluidic device designs, software, and specifications. This platform aims to lower barriers for researchers and enthusiasts to build and utilize microfluidic systems for biological experiments.

Area of Science:

  • Synthetic Biology
  • Bioengineering
  • Open Science

Background:

  • Microfluidic devices offer automation and miniaturization for biological experiments.
  • Widespread adoption is hindered by cost, complexity, and custom setups.
  • Open-source sharing of microfluidic designs has not kept pace with other scientific resources.

Purpose of the Study:

  • To establish Metafluidics, an open-source, community-driven repository for microfluidic device resources.
  • To facilitate the building, configuration, and operation of microfluidic devices.
  • To lower the barrier to entry for microfluidic research.

Main Methods:

  • Developed Metafluidics, a repository hosting digital design files, assembly specifications, and open-source software.
  • Shared designs and fabrication instructions for a microfluidic ring-mixer and a 32-channel controller.

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  • Applied the devices to construct genetic circuits using standard DNA assembly methods.

    • Main Results:

    • Successfully shared open-source designs for microfluidic devices and controllers.
    • Demonstrated the use of Metafluidics-provided resources for genetic circuit construction.
    • Enabled the application of microfluidics with standard DNA assembly techniques.

    Conclusions:

    • Metafluidics democratizes microfluidic technology by providing accessible, open-source resources.
    • The platform empowers a diverse community, including those with limited fabrication expertise, to engage in microfluidic research.
    • Facilitates broader participation and innovation in synthetic biology and bioengineering.