Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inverse relationship between neoantigen clonality and T-cell activity reveals distinct immune phenotypes in HNSCC.

Journal of translational medicine·2026
Same author

Demographic prompt cues shift clinical recommendations in multimodal large language models: a multi-model audit of 25,380 dental radiograph assessments.

BMC oral health·2026
Same author

Antimicrobial Stewardship in oral and maxillofacial surgery: melting the iceberg.

Antimicrobial stewardship & healthcare epidemiology : ASHE·2026
Same author

Dislocation angle predicts complications following mandibular condylar fracture treatment: a retrospective cohort study.

Frontiers in oral health·2026
Same author

Quantifying the Oral Cancer Public Awareness Deficit in Germany (2015-2023).

Cancers·2026
Same author

Radiation-induced oral side effects in head and neck cancer: a scoping review and interdisciplinary recommendations.

BMC oral health·2026

Related Experiment Video

Updated: Mar 1, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

22.1K

Vertical bone regeneration using rhBMP-2 and VEGF.

Lara Schorn1, Christoph Sproll2, Michelle Ommerborn3

  • 1Department of Oral-, Maxillo- and Plastic Facial Surgery, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.

Head & Face Medicine
|June 9, 2017
PubMed
Summary
This summary is machine-generated.

Vertical bone augmentation for dental implants is enhanced using a collagenous matrix with bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF). This combination promotes significant new bone growth in a single procedure, improving implant osseointegration.

Keywords:
CytokinesTissue engineeringVEGFVertical bone regenerationrhBMP-2

More Related Videos

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
09:34

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

9.9K
Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
13:16

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Published on: December 22, 2015

11.9K

Related Experiment Videos

Last Updated: Mar 1, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

22.1K
Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
09:34

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

9.9K
Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
13:16

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Published on: December 22, 2015

11.9K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Dental Implantology

Background:

  • Osseointegration of dental implants requires adequate bone volume and effective healing.
  • Vertical bone augmentation is challenging, particularly regarding bone volume stability.
  • Current techniques like bone grafts and guided bone regeneration have limitations.

Purpose of the Study:

  • To evaluate the efficacy of a collagenous scaffold (Insoluble Collagenous Bone Matrix - ICBM) combined with rhBMP-2 and VEGF for three-dimensional vertical bone generation.
  • To assess the potential of local delivery of rhBMP-2 and VEGF for inducing new vertical bone around dental implants in a one-stage procedure.

Main Methods:

  • 108 titanium implants were placed in mini pig mandibles and tibias.
  • Four groups were tested: Control, ICBM, ICBM + BMP-2, and ICBM + BMP-2 + VEGF.
  • Bone regeneration was analyzed histologically and histomorphometrically after 1, 4, and 12 weeks.

Main Results:

  • The combination of ICBM + rhBMP-2 + VEGF significantly increased bone volume density (BVD%) after 12 weeks.
  • This group also demonstrated superior vertical bone gain (VBG) and proportionally more vertical bone gain around the implant (PVBG) compared to controls.
  • Significant improvements in bone regeneration were observed with the combined growth factor approach.

Conclusions:

  • Collagenous matrices with rhBMP-2 and VEGF can achieve vertical bone generation in a one-stage procedure, avoiding donor site morbidity.
  • Local application of rhBMP-2 and VEGF via a collagenous carrier effectively enhances vertical bone regeneration in vivo.
  • Further investigation is warranted to determine the clinical applicability of this combined technique.