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Primary breast diffuse large B-cell lymphoma in a male
Kiyonobu Tokuyama1, Yasuaki Uemoto2, Satoshi Kitagawa3
1Department of Hematology, Toyota Memorial Hospital.
Summary
A 74-year-old man with right breast mass was diagnosed with diffuse large B-cell lymphoma. Treatment with R-CHOP chemotherapy and intrathecal chemotherapy led to complete remission.
Area of Science:
- Oncology
- Hematology
- Immunology
Background:
- Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma.
- Primary breast lymphoma is rare, with DLBCL being the most common subtype.
- Early diagnosis and appropriate staging are crucial for effective treatment.
Observation:
- A 74-year-old male presented with a right breast mass.
- Core needle biopsy confirmed diffuse large B-cell lymphoma.
- Ann Arbor stage IIA, low-intermediate international prognostic index.
Findings:
- The patient received six cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone).
- Four courses of intrathecal chemotherapy were administered.
- Complete remission was achieved following treatment.
Implications:
- This case highlights the successful treatment of primary breast DLBCL.
- R-CHOP chemotherapy combined with intrathecal chemotherapy is effective for localized DLBCL.
- Multidisciplinary care is essential for managing rare presentations of lymphoma.
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