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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Therapeutic strategies for atherosclerosis and atherothrombosis: Past, present and future

Christian Weber1, Lina Badimon, François Mach

  • 1Dr. Christian Weber or Dr. Emiel van der Vorst, Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Pettenkoferstr. 9, 80336 Munich, Germany, Tel.: +49 89 4400 54610, Fax: + 49 89 4400 54352, E-mail: christian.weber@med.uni-muenchen.de or, Emiel.Van_der_Vorst@med.uni-muenchen.de.

Thrombosis and Haemostasis
|June 9, 2017
PubMed

Insights

Atherosclerosis and atherothrombosis are major global health threats. This review covers current and emerging anti-inflammatory therapies to reduce residual risk and improve patient outcomes.

Area of Science:

  • Cardiovascular Medicine
  • Inflammation Research
  • Pharmacology

Background:

  • Atherosclerosis and atherothrombosis are leading global causes of mortality.
  • Understanding has evolved from lipid-driven to a multifactorial inflammatory process.
  • This shift necessitates novel anti-inflammatory therapeutic strategies.

Purpose of the Study:

  • To provide a historical overview of atherosclerosis and atherothrombosis research.
  • To review current state-of-the-art therapies for these conditions.
  • To highlight promising future therapeutic strategies and clinical investigations.

Main Methods:

  • Literature review of historical data and current research.
  • Synopsis of existing therapeutic options for atherosclerosis and atherothrombosis.
  • Analysis of ongoing investigations into novel and combination therapies.

Main Results:

  • Current therapies address aspects of atherosclerosis and atherothrombosis.
  • Significant residual risk persists despite existing treatments.
  • Emerging anti-inflammatory and combination therapies show promise.

Conclusions:

  • Continued research and clinical trials are crucial for advancing treatment.
  • Novel therapeutic combinations aim to further reduce residual cardiovascular risk.
  • Future developments promise improved management of atherosclerosis and atherothrombosis.

Keywords:
Atherosclerosisatherothrombosistherapeutic strategies

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