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Updated: Feb 28, 2026

Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation

Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation

Published on: January 12, 2016

Reliability of White Matter Microstructural Changes in HIV Infection: Meta-Analysis and Confirmation.

E E O'Connor¹, A Jaillard^2,3, F Renard^2,3

¹From the Department of Radiology and Nuclear Medicine (E.E.O.), University of Maryland Medical System, Baltimore, Maryland erin.oconnor@umm.edu.

AJNR. American Journal of Neuroradiology

|June 10, 2017

Summary

This summary is machine-generated.

Diffusion tensor imaging (DTI) shows HIV impacts white matter microstructure, but results vary. DTI measures are reliable over time in HIV patients, suggesting potential as disease markers.

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Area of Science:

Neuroimaging
Biomedical Engineering
Infectious Diseases

Background:

Diffusion tensor imaging (DTI) is crucial for assessing HIV-related white matter changes.
Previous studies show inconsistencies in DTI measures like fractional anisotropy and mean diffusivity in HIV patients.

Purpose of the Study:

Evaluate consistency of HIV effects on DTI measures across studies.
Assess the reliability of DTI in a longitudinal cohort of HIV-positive individuals.

Main Methods:

Conducted a meta-analysis of 16 cross-sectional studies for fractional anisotropy and 12 for mean diffusivity.
Estimated DTI longitudinal reliability in HIV-positive participants over 6 months of treatment.

Main Results:

Meta-analysis indicated lower fractional anisotropy and higher mean diffusivity in HIV patients, with significant heterogeneity.
Longitudinal data showed higher fractional anisotropy and lower mean diffusivity, with high stability (ICC >0.96) over 6 months.

Conclusions:

Substantial variations in reported HIV effects on white matter microstructure exist.
Controlled DTI acquisition and processing yield reliable, stable measures.
DTI's high longitudinal reliability makes it a promising marker for HIV disease activity.