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Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
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Pharmacological management
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Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Implementation of a proton pump inhibitor stewardship program.

Kelly W Davis1, Rachel E Hanners2, Sean M Lockwood2

  • 1Lexington Veterans Affairs Medical Center, Lexington, KY. kellya.davis@va.gov.

American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
|June 10, 2017
PubMed
Summary
This summary is machine-generated.

A new proton pump inhibitor (PPI) stewardship program was implemented to reduce overuse and ensure appropriate use of these medications. The program evaluated patients for PPI continuation, improving medication management and patient safety.

Keywords:
antacidsanti-ulcer agentsgastric acidgastroesophageal refluxgastrointestinal tractproton pump inhibitor

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Area of Science:

  • Pharmacology
  • Internal Medicine
  • Healthcare Management

Background:

  • Proton pump inhibitors (PPIs) are frequently overused.
  • Long-term PPI therapy is associated with adverse drug events.
  • There is a need for structured programs to optimize PPI use.

Purpose of the Study:

  • To describe the development and implementation of a PPI stewardship program.
  • To ensure appropriate continuation of PPI therapy for internal medicine patients.
  • To reduce unnecessary PPI utilization within a medical center.

Main Methods:

  • A PPI stewardship team evaluated internal medicine patients.
  • Criteria were established for appropriate PPI continuation during hospitalization and post-discharge.
  • PPI therapy was suspended for non-adherent patients, replaced with PRN acid suppressive therapy.
  • Patients received counseling on medication regimen changes.

Main Results:

  • The program aimed to reduce PPI overuse.
  • It focused on appropriate indication assessment for PPI continuation.
  • Challenges included defining criteria and managing PPI discontinuation to prevent rebound hyperacidity.

Conclusions:

  • A PPI stewardship program was successfully developed and implemented.
  • The program ensures appropriate PPI use for admitted and discharged patients.
  • This initiative addresses concerns regarding PPI overuse and associated risks.