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Updated: Feb 28, 2026
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
[Malignant melanoma of the urinary bladder]
1Urologische Klinik, Städtische Kliniken Neuss - Lukaskrankenhaus - GmbH, Preußenstraße 84, 41464, Neuss, Deutschland. thomas_otto@lukasneuss.de.
Abstract:
Primary malignant melanoma of the genitourinary tract is a rare lesion. We report the case of a 52-year-old man with primary manifestation of metastatic melanoma in the bladder. Multimodal therapy with transurethral tumor resection and systemic interferon/dacarbazine was not successful and the patient died 18 months later. Currently immune checkpoint inhibitors, CTLA-4 (cytotoxic T lymphocyte antigen-4) and PD-L1 are currently being tested in phase III studies and show long-lasting response in the case of classical melanoma manifestations.
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