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An Orthotopic Murine Model of Human Prostate Cancer Metastasis
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An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

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The role of peroxisome proliferator-activated receptor gamma in prostate cancer

Catherine Elix1, Sumanta K Pal1, Jeremy O Jones1

  • 1Department of Medical Oncology, City of Hope National Medical Center, Duarte, CA91010, USA.

Asian Journal of Andrology
|June 10, 2017
PubMed

Insights

Peroxisome proliferator-activated receptor gamma (PPARγ) was initially considered a tumor suppressor in prostate cancer. New research indicates PPARγ inhibition may be a novel therapeutic strategy for prostate cancer prevention and treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Drug Discovery

Background:

  • Prostate cancer presents a significant health and economic challenge.
  • Androgen receptor (AR) signaling is crucial, but other pathways also drive disease progression.
  • Novel therapeutic targets are needed for effective prostate cancer prevention and treatment.

Purpose of the Study:

  • To investigate the role of peroxisome proliferator-activated receptor gamma (PPARγ) in prostate cancer.
  • To evaluate PPARγ as a potential therapeutic target for prostate cancer.

Main Methods:

  • Analysis of existing research on PPARγ's function in prostate cells.
  • Review of recent unbiased studies identifying PPARγ as a target.
  • Evaluation of the potential of PPARγ inhibition in prostate cancer.

Main Results:

  • PPARγ's role in prostate cancer is complex; initial tumor suppressor theories are challenged.
  • PPARγ expression correlates with increased cancer grade and stage.
  • Two independent studies identified PPARγ as a viable target for intervention.

Conclusions:

  • PPARγ activity may contribute to prostate cancer development and progression.
  • Inhibition of PPARγ shows promise for prostate cancer prevention and treatment.
  • PPARγ represents a potential new therapeutic target in the fight against prostate cancer.
Keywords:
PPAR gammaandrogen receptorpreventionprostate cancerwarfarin

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