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Updated: Feb 28, 2026

Whole-cell MALDI-TOF Mass Spectrometry is an Accurate and Rapid Method to Analyze Different Modes of Macrophage Activation

Whole-cell MALDI-TOF Mass Spectrometry is an Accurate and Rapid Method to Analyze Different Modes of Macrophage Activation

Published on: December 26, 2013

Macrophage Activation Syndrome.

P Babu Raj¹, B L Harikrishnan², Roshan Mampilly³

¹Professor and Unit Chief.

The Journal of the Association of Physicians of India

|June 10, 2017

Summary

This summary is machine-generated.

Macrophage Activation Syndrome (MAS), a severe complication of rheumatic diseases, can present unusually. This case highlights MAS manifesting as fever and low blood counts without a clear cause.

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Area of Science:

Rheumatology
Hematology
Immunology

Background:

Macrophage Activation Syndrome (MAS) is a life-threatening complication associated with chronic rheumatic diseases.
It is particularly prevalent in systemic onset juvenile arthritis and adult onset Still's disease.
MAS can be triggered by various factors including infections, malignancies, and autoimmune conditions.

Observation:

This report details a case where MAS presented as pyrexia of unknown origin (PUO).
The patient also exhibited pancytopenia, a significant reduction in all blood cell types.
Crucially, no known triggering factor for MAS was identified in this instance.

Findings:

The study identifies an atypical presentation of Macrophage Activation Syndrome.
It emphasizes the diagnostic challenge posed by MAS when common triggers are absent.
The case underscores the importance of considering MAS in unexplained fever and pancytopenia.

Implications:

This case broadens the understanding of MAS presentations.
It suggests that MAS should be considered even in the absence of typical triggers.
Further research may elucidate rarer etiologies and diagnostic pathways for MAS.