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Related Concept Videos

Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

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Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
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Acute Coronary Syndrome III: Diagnostic Studies01:30

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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Myocarditis II: Clinical Features and Diagnostic Tests01:27

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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

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The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Troponins
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Related Experiment Video

Updated: Feb 28, 2026

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
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[Layer-specific Analysis in Patients with ST Segment Elevation Myocardial Infarction].

He Huang1, Xiao-Qin Liu1, Bao-Tao Huang1

  • 1Department of Cardiology, West China Hospital, Sichuan University,Chengdu 610041,China.

Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition
|June 10, 2017
PubMed
Summary

Layer-specific analysis of left ventricular function after ST-segment elevation myocardial infarction (STEMI) reveals that longitudinal epicardial strain predicts left ventricular remodeling (LVR). This finding aids in assessing cardiac function post-STEMI.

Keywords:
Layer-specific analysisLeft ventricular remodelingMyocardial infarction

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Histological Quantification of Chronic Myocardial Infarct in Rats
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Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • ST-segment elevation myocardial infarction (STEMI) can lead to adverse left ventricular remodeling (LVR).
  • Assessing regional myocardial function is crucial for predicting LVR after STEMI.
  • Layer-specific analysis offers a more detailed evaluation of ventricular wall mechanics.

Purpose of the Study:

  • To evaluate left ventricular (LV) wall function using layer-specific analysis after STEMI.
  • To determine if layer-specific parameters can predict LVR.
  • To investigate changes in myocardial strain in STEMI patients.

Main Methods:

  • Studied 39 patients with first STEMI post-primary percutaneous coronary intervention (P-PCI) and 30 healthy controls.
  • Performed echocardiography within 48 hours and 6 months after P-PCI.
  • Analyzed 3D cardiac function and longitudinal/circumferential 3-layer strain.

Main Results:

  • Circumferential strain decreased from endocardium to epicardium in STEMI patients.
  • Longitudinal and circumferential 3-layer strain improved at 6 months but remained lower than in controls.
  • Lower longitudinal and circumferential 3-layer strain were observed in the LVR group.
  • Longitudinal epicardial strain independently predicted LVR (OR: 3.332, P=0.03).

Conclusions:

  • Myocardial strain distribution varies by layer in STEMI patients within 48 hours post-P-PCI.
  • Reduced myocardial function is associated with LVR.
  • Longitudinal epicardial strain is a significant predictor of LVR after STEMI.