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Updated: Feb 28, 2026

Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model

Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model

Published on: February 8, 2022

Hormonal Changes in Intracranial Hemorrhage.

R Shrestha¹, R Pradhan², M M Pradhan³

¹Department of Orthopaedics, Nepalese Army Institute of Health Sciences, Kathmandu, Nepal, Department of Neurosurgery, West China Hospital, Sichuan University, China.

JNMA; Journal of the Nepal Medical Association

|June 10, 2017

Summary

This summary is machine-generated.

Serum Triiodothyronine (T3) and free T3 levels significantly change in the acute phase of intracerebral hemorrhage (ICH). These hormonal changes correlate with ICH volume and Glasgow Coma Scale (GCS) score, indicating their importance in assessing disease severity.

Keywords:

ACTH; ICH; lymphocyte ICH; Thyroid hormone.

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Area of Science:

Endocrinology
Neurology
Critical Care Medicine

Background:

Intracerebral hemorrhage (ICH) is a critical neurological condition.
Understanding acute-phase hormonal changes is vital for patient management.

Purpose of the Study:

To investigate serum Adrenocorticotropic hormone (ACTH) and thyroid hormone level alterations in the acute phase of ICH.
To correlate these hormonal changes with clinical and radiological parameters.

Main Methods:

Sixty spontaneous ICH patients were evaluated for ACTH and thyroid hormone levels.
Hormone concentrations were measured at admission, day 5, and day 10.
Statistical analysis was performed to assess hormone levels and their relationship with ICH volume and GCS score.

Main Results:

While ACTH, TSH, Thyroxine, and free Thyroxine showed no significant changes over time, Triiodothyronine (T3) and free Triiodothyronine (FT3) levels varied significantly (P < 0.05).
T3 and FT3 levels did not differ based on hemorrhage location.
Significant negative correlations were observed between T3/FT3 and ICH volume, and positive correlations with GCS score on admission.

Conclusions:

Hormonal secretion patterns, particularly T3 and FT3, are associated with ICH severity.
These hormonal markers serve as important indices for evaluating disease severity and prognosis in ICH patients.