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Updated: Feb 28, 2026

Collection and Extraction of Occupational Air Samples for Analysis of Fungal DNA
Published on: May 2, 2018
Distinct Clinical Phenotypes of Occupational Asthma due to Diisocyanates
Paola Mason1, Maria Cristina Scarpa, Filippo Liviero
1Department of Cardiologic, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
Objective:
To assess whether diisocyanate occupational asthma represents a unique phenotype.
Methods:
We studied 187 patients with diagnosis of asthma due to diisocyanates confirmed by a positive specific inhalation challenge. The simplified algorithm from severe asthma research program (SARP) (Moore et al, 2010) was applied to classify patients into five clusters.
Results:
Our patients were allocated in three of the five clusters described in common asthma, since the most severe Clusters (4 and 5) were not represented. Cluster 2 was the most populated, as in common asthma, and included the youngest patients with the shortest duration of exposure to the sensitizers. Cluster 3 included older men patients with worse lung function and longer occupational exposure.
Conclusions:
Diisocyanate asthma is a heterogeneous disease. Differences across clusters include demographic characteristics, lung function, and chronology of diisocyanate exposure.
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