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Acoustic force measurements on polymer-coated microbubbles in a microfluidic device
Gianluca Memoli1, Christopher R Fury1, Kate O Baxter1
1Department of Acoustics, National Physical Laboratory, Hampton Road, Teddington TW11 0LW, United Kingdom.
The Journal of the Acoustical Society of America
|June 11, 2017
Summary
This study introduces an acoustofluidic device for precise microbubble manipulation using combined optical and acoustic tweezers. It details methods for accurate acoustic pressure measurement, crucial for biomedical applications.
Area of Science:
- Acoustofluidics
- Biophysics
- Optical Tweezers
Background:
- Microbubble manipulation is vital for various biomedical applications.
- Precise characterization of acoustic fields is essential for controlling microbubbles.
Purpose of the Study:
- To develop and characterize an acoustofluidic device for manipulating coated microbubbles.
- To enable simultaneous use of optical and acoustic tweezers for precise control.
Main Methods:
- Combined use of laser vibrometry, finite element modeling, and holographic optical tweezers.
- Particle tracking with polystyrene beads for quantitative acoustic pressure measurements.
- Extension of tracking to microbubbles with negative acoustophoretic contrast factor.
Main Results:
- Comprehensive characterization of acoustic pressure within the device.
- Accurate measurement of acoustic forces acting on isolated microbubbles.
- Identification of four distinct peaks in the device's acoustic response.
Conclusions:
- The developed device and methodologies allow precise acoustic field characterization.
- Results are applicable to acoustofluidic and biomedical applications involving microbubbles or deformable particles.
