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Related Experiment Videos

Drug discrimination studies.

S G Holtzman

    Drug and Alcohol Dependence
    |February 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Opioid drugs can be classified into three groups based on their effects in animals and humans. These classifications are linked to their potential for abuse.

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    Area of Science:

    • Pharmacology
    • Neuroscience
    • Drug Abuse Research

    Background:

    • Opioid agonists and agonist/antagonants exhibit diverse stimulus properties.
    • Evidence suggests multiple receptor populations mediate opioid actions.

    Purpose of the Study:

    • To categorize opioid compounds based on their discriminative stimulus properties.
    • To correlate these properties with potential for abuse in humans.

    Main Methods:

    • Classification of opioid compounds into three groups based on animal discriminative stimulus properties.
    • Assessment of antagonist blockade at different doses (naloxone, naltrexone).
    • Evaluation of subjective effects in humans (morphine-like, dysphoric, psychotomimetic).

    Main Results:

    Related Experiment Videos

    • Group 1: Morphine/fentanyl-like effects, blocked by low antagonist doses.
    • Group 2: Ethylketocyclazocine/nalorphine-like effects, blocked by higher antagonist doses.
    • Group 3: N-allylnormetazocine/phencyclidine-like effects, not blocked by antagonists.
    • Human subjective effects correlate with animal stimulus properties: Group 1 is reinforcing, Groups 2 & 3 are dysphoric/psychotomimetic.

    Conclusions:

    • Discriminative stimulus properties of opioids reflect neuronal actions.
    • These properties are directly relevant to the potential for opioid abuse in humans.