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Comparison of sequential vaginal and sublingual misoprostol after a vaginal loading dose for second-trimester
Ming-Chao Huang1, Ching-Hung Hsieh2, Jian-Pei Huang3
1Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Obstetrics and Gynecology, MacKay Memorial Hospital, Hsinchu, Taiwan; MacKay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan.
Objective:
To evaluate the effects of sequential vaginal and sublingual misoprostol after a vaginal loading dose for second-trimester abortion.
Materials And Methods:
From January 2006 to December 2011, 173 women received an 800-μg vaginal loading dose of misoprostol. After the loading dose, 103 patients received 800 mg of misoprostol vaginally and 70 patients received 400 mg of misoprostol sublingually every 12 h until the delivery of the fetus.
Results:
In the vaginal group, the average abortion time was 1.07 ± 1.29 days; that was 0.82 ± 0.66 days in the sublingual group. Sequential sublingual misoprostol after a vaginal loading dose of 800 mg with an administration interval of 12 h had a similar abortion rate and time to abortion. In addition, this protocol reduced unnecessary digital pelvic examinations and speculum examinations.
Conclusion:
This sequential sublingual misoprostol regimen might be a suitable regimen for mid-trimester abortion.
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