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Retinal vessels functionality in eyes with central serous chorioretinopathy
Livia Tomasso1, Lucia Benatti1, Alessandro Rabiolo1
1Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, Italy.
The British Journal of Ophthalmology
|June 11, 2017
Summary
Central serous chorioretinopathy (CSCR) eyes show reduced retinal venous dilation during flicker light stimulation. This finding, along with increased choroidal thickness, offers insights into CSCR pathogenesis.
Area of Science:
- Ophthalmology
- Retinal Vascular Physiology
- Medical Imaging
Background:
- Central serous chorioretinopathy (CSCR) is a condition affecting the retina.
- Understanding the functional and structural changes in retinal vessels in CSCR is crucial for elucidating its pathogenesis.
Purpose of the Study:
- To analyze the static and dynamic characteristics of retinal vessels in patients with CSCR using Dynamic Vessel Analyzer (DVA).
- To compare retinal vessel function between CSCR patients and healthy controls.
Main Methods:
- A study involving 28 eyes of 28 subjects (14 CSCR, 14 controls) matched for age and sex.
- Retinal vessel analysis using Dynamic Vessel Analyzer (DVA) during flicker light stimulation.
- Optical coherence tomography (OCT) to measure subfoveal choroidal thickness.
Main Results:
- CSCR eyes exhibited significantly reduced mean venous dilation (3.3%) compared to controls (5.5%) during flicker stimulation (p=0.0258).
- No significant difference in mean arterial dilation was observed between groups.
- Subfoveal choroidal thickness was significantly increased in CSCR eyes (438.6 µm) compared to controls (301.5 µm) (p=0.0001).
Conclusions:
- Dynamic analysis revealed impaired retinal venous response to flicker light in CSCR.
- This reduced venous dilation, potentially linked to increased sympathetic tone and venous stasis, alongside thickened choroid, may contribute to CSCR development.
- Findings provide insights into the pathophysiology of central serous chorioretinopathy.
