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Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
Published on: April 26, 2019
Hirschsprung Disease - Current Diagnosis and Management
Kanishka Das1, Suravi Mohanty2
1Department of Pediatric Surgery, St. John's Medical College & Hospital, Bangalore, Karnataka, 560034, India. kanishkadas@hotmail.com.
Hirschsprung disease, a congenital condition causing large bowel obstruction in infants, involves aganglionosis from the rectum. Diagnosis and surgical treatments have advanced, with this review detailing current best practices and the Indian context.
Area of Science:
- Pediatric surgery
- Gastroenterology
- Medical diagnostics
Background:
- Hirschsprung disease is a primary cause of intestinal obstruction in neonates and infants.
- It is defined by the absence of ganglion cells in the distal bowel, extending proximally from the anus.
- Historical understanding and treatment of this condition have significantly evolved.
Purpose of the Study:
- To provide a comprehensive overview of current diagnostic methods for Hirschsprung disease.
- To outline optimal surgical management strategies for Hirschsprung disease.
- To discuss the specific context of Hirschsprung disease within India.
Main Methods:
- Review of current literature on Hirschsprung disease diagnosis.
- Analysis of contemporary surgical techniques for Hirschsprung disease management.
- Inclusion of data and insights relevant to the Indian healthcare landscape.
Main Results:
- Advances in histological evaluation have improved diagnostic accuracy.
- Surgical techniques have been refined for better patient outcomes.
- The article synthesizes current knowledge for clinical application.
Conclusions:
- Optimal management involves accurate diagnosis and appropriate surgical intervention.
- Continuous advancements are enhancing the treatment of Hirschsprung disease.
- Understanding the Indian scenario provides valuable regional insights.
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