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Oxidized LDL but not total LDL is associated with HbA1c in individuals without diabetes

Débora Spessatto1, Liz Marina Bueno Dos Passos Brum2, Joíza Lins Camargo3

  • 1Graduate Program in Medical Sciences: Endocrinology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|June 12, 2017
PubMed

Insights

Glycated hemoglobin (HbA1c) is linked to oxidized LDL (oxi-LDL) in non-diabetics. Higher oxi-LDL indicates increased risk for diabetes and cardiovascular disease, suggesting HbA1c can identify at-risk individuals.

Area of Science:

  • Cardiovascular Health
  • Metabolic Syndrome Research
  • Biomarker Discovery

Background:

  • Glycated hemoglobin (HbA1c) reflects average blood glucose over time.
  • Oxidized low-density lipoprotein (oxi-LDL) is implicated in atherosclerosis.
  • Understanding their relationship in non-diabetic individuals is crucial for early risk assessment.

Purpose of the Study:

  • To investigate the association between HbA1c, LDL, and oxi-LDL in individuals without diabetes.
  • To determine if HbA1c can serve as a biomarker for identifying individuals at risk of developing complications.

Main Methods:

  • 196 non-diabetic individuals were enrolled and categorized into three groups based on HbA1c and fasting plasma glucose.
  • Measurements included HbA1c, oxi-LDL, LDL, and lipid profiles.
  • Multiple linear regression analysis was used to adjust for confounding variables.

Main Results:

  • Significant differences in oxi-LDL levels were observed across all groups, with the highest in group 3 (p<0.001).
  • HbA1c showed moderate positive associations with oxi-LDL, oxi-LDL/HDL, and oxi-LDL/LDL ratios (p<0.001).
  • Traditional atherogenic lipids like LDL and triglycerides showed only weak associations with HbA1c.

Conclusions:

  • Oxi-LDL levels are significantly associated with HbA1c in non-diabetic individuals.
  • Elevated oxi-LDL is linked to higher risk for diabetes and cardiovascular disease.
  • HbA1c may be a valuable biomarker for identifying at-risk individuals even with non-diabetic glycemic levels.
Abstract

Keywords:
DiabetesGlycated hemoglobinOxidized cholesterol LDL

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