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Related Experiment Video

Updated: Feb 28, 2026

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex

Published on: February 8, 2020

Visuomotor Coupling Shapes the Functional Development of Mouse Visual Cortex.

Alexander Attinger¹, Bo Wang¹, Georg B Keller¹

¹Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland; Faculty of Natural Sciences, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland.

|June 13, 2017

Summary

This summary is machine-generated.

Sensorimotor coupling is crucial for developing visual processing in the mouse brain. Specific neural circuits in the primary visual cortex fine-tune this connection through experience.

Keywords:

predictive coding sensorimotor integration somatostatin interneurons visual cortex

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Area of Science:

Neuroscience
Developmental Neuroscience
Systems Neuroscience

Background:

Sensory-guided behaviors emerge from sensorimotor coupling during development.
The precise mechanisms by which sensorimotor experience shapes neural processing remain largely unknown.

Purpose of the Study:

To investigate the necessity of sensorimotor coupling for the functional development of visual processing in layer 2/3 (L2/3) of the primary visual cortex (V1).
To elucidate how neural processing in V1 is shaped by sensorimotor experience.

Main Methods:

Utilized a virtual reality system to rear mice under conditions of normal or random visuomotor coupling.
Recorded the activity of identified excitatory and inhibitory L2/3 neurons in response to visuomotor mismatches.

Main Results:

Mismatch responses in excitatory neurons were significantly experience-dependent.
These responses were mediated by a transient release from inhibition involving somatostatin-positive interneurons.
Evidence supports a model where V1 L2/3 integrates visual and locomotion-related inputs, balanced by visuomotor experience.

Conclusions:

Visuomotor coupling is essential for the proper development of visual processing in mouse V1 L2/3.
Somatostatin-positive interneurons play a key role in mediating experience-dependent visual processing.
Neural circuits in V1 dynamically adjust based on sensorimotor experience to support behavior.