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DNA-Targeted Precision Medicine; Have we Been Caught Sleeping?
William C Reinhold1, Anish Thomas1,2, Yves Pommier1
1Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892.
Molecular markers are increasingly used in precision medicine, but the omission of DNA damage drugs is a significant oversight. This approach neglects a crucial class of therapies for personalized treatment selection.
Area of Science:
- Oncology
- Pharmacology
- Genetics
Background:
- Precision medicine aims to tailor treatments using molecular markers.
- DNA damage drugs are a major class of routinely used therapeutics.
- Current precision medicine strategies often overlook DNA damage agents.
Purpose of the Study:
- To highlight the omission of DNA damage drugs in precision medicine.
- To advocate for the inclusion of DNA damage mechanisms in treatment selection.
- To emphasize the importance of these drugs in personalized therapy.
Main Methods:
- Literature review of current precision medicine approaches.
- Analysis of drug classification based on mechanism of action.
- Comparative study of marker-guided therapies versus DNA damage agents.
Main Results:
- Identified a significant gap in precision medicine regarding DNA damage drugs.
- Demonstrated the widespread use and efficacy of DNA damage therapies.
- Highlighted the potential for improved patient outcomes by integrating these drugs.
Conclusions:
- The exclusion of DNA damage drugs from molecular marker-driven treatment selection is ill-advised.
- Incorporating DNA damage mechanisms is essential for comprehensive precision medicine.
- Future strategies must account for these critical therapeutic agents.
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