Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Spatio-temporal genomics of goats: recent evolution, adaptation, and future vulnerability.

Animal : an international journal of animal bioscience·2026

Same author

Uncovering genomic traces of local adaptation and milk production traits in the Comisana Sheep, a Mediterranean dairy breed.

Animal : an international journal of animal bioscience·2025

Same author

A comparison of genetic and genomic breeding values in Saanen and Alpine goats.

Animal : an international journal of animal bioscience·2024

Same author

Four-year overall survival update from the phase III HIMALAYA study of tremelimumab plus durvalumab in unresectable hepatocellular carcinoma.

Annals of oncology : official journal of the European Society for Medical Oncology·2024

Same author

OnabotulinumtoxinA in elderly patients with chronic migraine: insights from a real-life European multicenter study.

Journal of neurology·2022

Same author

Tissue geometry drives deterministic organoid patterning.

Science (New York, N.Y.)·2022

Same journal

Reprocessable Disulfide-Based Vitrimers with Adhesive Properties.

Macromolecular rapid communications·2026

Same journal

Micro- and Nanopatterning of Highly Conductive PEDOT Thin Films.

Macromolecular rapid communications·2026

Same journal

From Molecular Structure to Macroscopic Performance: Insights into Polycarbosilane Curing.

Macromolecular rapid communications·2026

Same journal

High-Yield Synthesis of Molecular Bottlebrushes With Block Copolymer Side Chains by the Copper Superoxido Complex Enabled ATRP via a Grafting-From Approach.

Macromolecular rapid communications·2026

Same journal

Chemically and Mechanically Recyclable Polyolefins Incorporating Covalent Adaptable Networks.

Macromolecular rapid communications·2026

Same journal

Designing Thermally Stable DNA Hydrogels via Entropically-Driven Acridine Intercalation.

Macromolecular rapid communications·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 28, 2026

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Microfluidic Programming of Compositional Hydrogel Landscapes.

S Allazetta¹, A Negro¹, M P Lutolf^1,2

¹Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences and School of Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.

Macromolecular Rapid Communications

|June 13, 2017

Summary

This summary is machine-generated.

This study introduces a droplet microfluidics method for quickly creating and testing many synthetic hydrogels. This approach accelerates the discovery of new hydrogel materials for diverse applications.

Keywords:

droplets high-throughput screening hydrogel microfluidics

More Related Videos

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices

Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices

Published on: January 27, 2017

Related Experiment Videos

Last Updated: Feb 28, 2026

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices

Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices

Published on: January 27, 2017

Area of Science:

Materials Science
Chemical Engineering
Biotechnology

Background:

Hydrogels are versatile materials with applications in drug delivery, tissue engineering, and diagnostics.
Discovering novel hydrogel formulations with specific properties can be time-consuming and resource-intensive.
High-throughput synthesis and screening methods are needed to accelerate hydrogel innovation.

Purpose of the Study:

To develop a droplet microfluidics strategy for rapid synthesis and screening of synthetic hydrogels.
To enable systematic modulation of hydrogel composition and properties.
To accelerate the discovery of new hydrogel formulations for various applications.

Main Methods:

Utilized droplet microfluidics to synthesize hundreds of thousands of compositionally distinct synthetic hydrogels.
Programmed flow rates of microfluidic channels to control hydrogel building block ratios.
Employed fluorescent labels as proxies for physical and chemical properties.
Performed rapid screening using fluorescence microscopy and flow cytometry.

Main Results:

Successfully synthesized and processed a large library of unique synthetic hydrogels.
Demonstrated systematic control over microgel composition and properties through flow rate programming.
Enabled rapid identification of specific hydrogel formulations via fluorescence-based screening.

Conclusions:

Droplet microfluidics offers a powerful platform for high-throughput hydrogel synthesis and screening.
This strategy significantly accelerates the discovery of novel hydrogel materials.
The approach has broad potential for advancing applications in medicine, engineering, and beyond.