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Is elimination of hepatitis C from the UK by 2030 a realistic goal?

Will Gelson1, Graeme Alexander1,2

  • 1Cambridge University Hospitals NHS Foundation Trust, Hill's Road, Cambridge, CB2 0QQ, UK.

British Medical Bulletin
|June 13, 2017
PubMed

Insights

New combination therapies offer nearly 100% cure rates for chronic hepatitis C virus (HCV) infection within 12 weeks. High drug costs and identifying hidden patient populations remain barriers to HCV elimination.

Area of Science:

  • Hepatology and Viral Gastroenterology
  • Infectious Diseases
  • Pharmacology

Background:

  • Chronic hepatitis C virus (HCV) infection is now treatable with highly effective combination therapies.
  • Current cure rates approach 100% across diverse patient populations and viral genotypes.
  • Treatment durations are short, typically 12 weeks, with minimal side effects compared to older interferon-based regimens.

Purpose of the Study:

  • To review the efficacy and safety of current chronic hepatitis C virus (HCV) treatments.
  • To explore the potential for HCV elimination given treatment advancements.
  • To identify barriers hindering HCV eradication efforts.

Main Methods:

  • Literature review of current antiviral agents for HCV.
  • Analysis of treatment outcomes, side effect profiles, and duration of therapy.
  • Examination of economic and public health challenges to HCV elimination.

Main Results:

  • Modern combination therapies demonstrate high efficacy and safety, achieving near-universal cure rates.
  • Treatment is well-tolerated with few adverse events.
  • Significant barriers to HCV elimination include high drug costs and the challenge of identifying and treating 'invisible' patient populations.

Conclusions:

  • Highly effective and safe treatments for chronic hepatitis C virus (HCV) infection are available, offering a pathway to potential elimination.
  • Reducing treatment costs and developing strategies to reach undiagnosed or disengaged individuals are critical for achieving HCV eradication.
Abstract

Keywords:
eradicationhepatitis C virus

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