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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Disorders of the Skeletal Muscle01:28

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The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
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Autoimmune Disorders01:29

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Adrenal Gland Disorders01:27

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Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
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Related Experiment Video

Updated: Feb 28, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Scleroderma-like Disorders.

Amit Sharma1

  • 1Fortis Escorts Hospital, Jaipur, Rajasthan, India.

Current Rheumatology Reviews
|June 14, 2017
PubMed
Summary
This summary is machine-generated.

Scleroderma involves skin hardening and tightening, potentially affecting internal organs. This review explores scleroderma variants, which mimic the condition but lack key diagnostic features like Raynaud phenomenon.

Keywords:
Scleroderma-like disorderseosinophilic fasciitisnephrogenicscleredemascleromyxedemasystemic fibrosis.

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Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
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Area of Science:

  • Dermatology
  • Rheumatology
  • Internal Medicine

Background:

  • Scleroderma is a group of diseases characterized by hardening and tightening of the skin and connective tissues.
  • It can be localized to the skin or involve internal organs in systemic sclerosis.

Purpose of the Study:

  • To differentiate scleroderma from similar-appearing conditions.
  • To review various disorders that mimic scleroderma, known as scleroderma variants or scleroderma-like disorders.

Main Methods:

  • Literature review of scleroderma variants.
  • Discussion of key differentiating features between scleroderma and its variants.

Main Results:

  • Scleroderma variants mimic scleroderma but typically lack specific features such as Raynaud phenomenon, sclerodactyly, and characteristic autoantibodies.
  • Identified variants include scleromyxedema, scleredema, nephrogenic systemic fibrosis, and eosinophilic fasciitis.

Conclusions:

  • Recognizing scleroderma variants is crucial for accurate diagnosis and management.
  • These variants present a diagnostic challenge due to their resemblance to true scleroderma.