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Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

1.5K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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Seizures: Classification01:13

Seizures: Classification

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Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
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Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

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Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
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Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

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γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
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Related Experiment Video

Updated: Feb 28, 2026

Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury
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The Progress of Epilepsy after Stroke.

Yinghao Zhao1, Xiangyan Li2, Kun Zhang3

  • 1Department of Thoracic Surgery, The Second Hospital of Jilin University; Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, Changchun, Jilin, China.

Current Neuropharmacology
|June 14, 2017
PubMed
Summary

Post-stroke epilepsy (PSE) is a common neurological disorder in elderly patients, often negatively impacting stroke prognosis and quality of life. This review synthesizes current research on PSE, covering its definition, risk factors, and management strategies.

Keywords:
Epilepsybrainpost-stroke epilepsyrisk factorseizurestroke

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Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
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Area of Science:

  • Neurology
  • Cerebrovascular Medicine
  • Epileptology

Background:

  • Epilepsy is a prevalent neurological disorder with diverse causes.
  • Cerebrovascular disease, particularly stroke, is the leading cause of epilepsy in the elderly, accounting for 30-50% of new cases.
  • Post-stroke epilepsy (PSE) affects 3-30% of stroke survivors.

Purpose of the Study:

  • To review current research on post-stroke epilepsy (PSE).
  • To summarize new findings on the definition, epidemiology, risk factors, mechanisms, diagnosis, and treatment of PSE.

Main Methods:

  • A comprehensive literature search was conducted using keywords 'Stroke' and 'epilepsy'.
  • Databases searched included Web of Science, Medline, Pubmed, and Scopus.

Main Results:

  • Post-stroke epilepsy (PSE) negatively impacts stroke prognosis and patient quality of life.
  • The incidence of PSE varies between 3% and 30% depending on the cerebrovascular disease.

Conclusions:

  • Understanding PSE is crucial for improving patient outcomes.
  • This review aims to enhance knowledge of PSE by consolidating recent research findings.