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Analysis of the psychometric properties of the Multiple Sclerosis Impact Scale-29 (MSIS-29) in relapsing-remitting

E D Bacci1, K W Wyrwich1, G A Phillips2

  • 1Evidera Inc, Outcomes Research, USA.

Multiple Sclerosis Journal - Experimental, Translational and Clinical
|June 14, 2017
PubMed
Abstract

Insights

The Multiple Sclerosis Impact Scale (MSIS-29v1) is a reliable tool for measuring physical and psychological impacts in relapsing-remitting multiple sclerosis (RRMS) patients during clinical trials. Its psychometric properties are sound for this patient population.

Area of Science:

  • Psychometrics
  • Clinical Trials
  • Neurology

Background:

  • Classical test theory supports the psychometric properties of the original Multiple Sclerosis Impact Scale (MSIS-29v1).
  • Rasch analysis of community samples led to revisions (MSIS-29v2).

Purpose of the Study:

  • Evaluate the psychometric properties of the MSIS-29v1.
  • Assess its utility in a clinical trial cohort of relapsing-remitting multiple sclerosis (RRMS) patients.

Main Methods:

  • Utilized data from 600 RRMS patients in the SELECT clinical trial.
  • Performed classical psychometric analyses, Item Response Theory (IRT), and Rasch analysis.
  • Assessed measurements at baseline and Weeks 12, 24, and 52.

Main Results:

  • Both MSIS-29v1 subscales showed strong reliability, construct validity, and responsiveness.
  • IRT and Rasch analyses supported response category threshold ordering, person-item fit, and item fit.

Conclusions:

  • The MSIS-29v1 demonstrated robust measurement properties across classical, IRT, and Rasch techniques.
  • The MSIS-29v1 is psychometrically sound for assessing physical and psychological impairments in RRMS patients within clinical trials.
Keywords:
Multiple Sclerosis Impact ScaleRasch modelgraded response modelitem response theoryrelapsing–remitting multiple sclerosisreliabilityresponsivenessvalidity

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