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Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay
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Covalent inhibitors: an opportunity for rational target selectivity

Roman Lagoutte1, Remi Patouret1, Nicolas Winssinger1

  • 1Faculty of Science, Department of Organic Chemistry, NCCR Chemical Biology, University of Geneva, 30 quai Ernest Ansermet, CH-1205 Geneva, Switzerland.

Current Opinion in Chemical Biology
|June 14, 2017
PubMed
Summary

Covalent inhibitors targeting cysteine or lysine residues offer precise drug design. Advances in structural biology and proteomics enhance the discovery and selectivity of these targeted therapies.

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