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Updated: Feb 28, 2026

Clinical Examination Protocol to Detect Atypical and Classical Scrapie in Sheep
Published on: January 19, 2014
"Typical symptoms in the atypical patient? Consider SCAD!"
Malissa J Wood1, Douglas E Drachman1
1Harvard Medical School, Division of Cardiology, Massachusetts General Hospital, 55 Fruit Street Blake 256, Boston, MA, 02114.
Insights
Spontaneous Coronary Artery Dissection (SCAD) may cause heart attacks in young adults. Doctors should test cardiac biomarkers and consider cardiac catheterization for suspected SCAD in patients with cardiac symptoms.
Area of Science:
- Cardiology
- Vascular Biology
- Diagnostic Imaging
Background:
- Spontaneous Coronary Artery Dissection (SCAD) is an underrecognized cause of cardiac ischemia, particularly in young, healthy individuals.
- Prompt evaluation of cardiac symptoms in this demographic is crucial for accurate diagnosis and timely intervention.
- Standard diagnostic pathways may not always identify SCAD, necessitating consideration of specific etiologies.
Discussion:
- Cardiac biomarker testing is recommended in the initial assessment of young patients presenting with potential cardiac symptoms.
- The presence of unstable symptoms or ongoing ischemia warrants consideration of cardiac catheterization.
- Cardiac catheterization serves as a critical tool for both diagnosing and treating Coronary Artery Disease (CAD), irrespective of its underlying cause, including SCAD.
Key Insights:
- SCAD should be considered in the differential diagnosis of cardiac ischemia in young patients without traditional risk factors.
- Early cardiac biomarker assessment aids in identifying myocardial injury.
- Cardiac catheterization is essential for definitive diagnosis and management of SCAD-related events.
Outlook:
- Further research is needed to elucidate the specific mechanisms and long-term outcomes associated with SCAD.
- Developing non-invasive diagnostic modalities for SCAD could improve early detection rates.
- Enhanced awareness among healthcare providers regarding SCAD is vital for improving patient care and outcomes.
Abstract:
Consider SCAD as a potential etiology of cardiac ischemia in young, otherwise healthy patients Cardiac biomarker testing should be included in the initial evaluation of young patients who present with possible cardiac symptoms If unstable symptoms/ongoing ischemia are present, cardiac catheterization should be considered to diagnose and treat CAD regardless of etiology.
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