Unsupervised Learning of Spike Patterns for Seizure Detection and Wavefront Estimation of High Resolution Micro...

For the past few years, we have developed flexible, active, and multiplexed recording devices for high resolution recording over large, clinically relevant areas in the brain. While this technology has enabled a much higher-resolution view of the electrical activity of the brain, the analytical methods to process, categorize, and respond to the huge volumes of seizure data produced by these devices have not yet been developed. In this paper, we proposed an unsupervised learning framework for spike analysis, which by itself reveals spike pattern. By applying advanced video processing techniques for separating a multi-channel recording into individual spike segments, unfolding the spike segments manifold, and identifying natural clusters for spike patterns, we are able to find the common spike motion patterns. And we further explored using these patterns for more interesting and practical problems as seizure prediction and spike wavefront prediction. These methods have been applied to in vivo feline seizure recordings and yielded promising results.