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Published on: September 27, 2017
Paternal vs. Maternal Factors in Childhood Atopic Dermatitis
Alexandra R Vaughn1, Raja K Sivamani, Peter A Lio
1From the *Drexel University College of Medicine, Philadelphia, PA; †Department of Dermatology, University of California, Davis; ‡Department of Dermatology and Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL; and §Department of Medicine, Dermatology Division, University of Arizona, Tucson.
Abstract:
Atopic dermatitis (AD) is a common inflammatory skin disease that chronically affects children and adults worldwide. Environmental exposures, heritable factors, immune dysregulation, and skin barrier malfunction all contribute to the multifactorial nature of AD. It is known that maternal and paternal influences are important predictors for the risk of AD in offspring. This review examines and compares the evidence and mechanisms behind specific maternal and paternal factors that may contribute to the pathogenesis of AD.
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