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Metabolic Regulation of Angiogenesis in Diabetes and Aging

Naoki Sawada1,1,2, Zolt Arany3

  • 1Department of Cell Biology and Molecular Medicine, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey.

Physiology (Bethesda, Md.)
|June 16, 2017
PubMed

Insights

Diabetes and aging impair blood vessel formation and function. New research highlights the role of endothelial intracellular molecules and energy production in improving blood vessel health for therapeutic potential.

Area of Science:

  • Vascular Biology
  • Endothelial Cell Metabolism
  • Diabetes and Aging Research

Background:

  • Impaired angiogenesis and endothelial dysfunction are key features of diabetes and aging.
  • Previous therapeutic strategies targeting growth factors for angiogenesis have yielded inconsistent outcomes.
  • Emerging evidence points to the significance of intracellular molecules within endothelial cells.

Purpose of the Study:

  • To review the emerging role of endothelial intracellular molecules in regulating angiogenesis.
  • To explore the therapeutic potential of targeting endothelial bioenergetics in diabetes and aging.
  • To provide an overview of current research on endothelial function in metabolic and age-related diseases.

Main Methods:

  • Literature review of recent studies on endothelial cell metabolism and angiogenesis.
  • Analysis of research on intracellular proteins involved in endothelial function.
  • Synthesis of findings related to therapeutic interventions in diabetes and aging.

Main Results:

  • Endothelial intracellular molecules are critical regulators of angiogenesis.
  • Endothelial bioenergetics plays a vital role in maintaining vascular health.
  • Targeting these pathways offers novel therapeutic avenues.

Conclusions:

  • Endothelial intracellular molecules and bioenergetics represent a promising area for therapeutic development.
  • Understanding these mechanisms is crucial for addressing angiogenesis impairment in diabetes and aging.
  • Further research into these targets could lead to improved treatments for vascular complications.

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