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Updated: Feb 28, 2026

Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Hyperresponsiveness: Relating the Intact Airway to the Whole Lung
Kenneth R Lutchen1, Peter D Paré2,3, Chun Y Seow3,4
1Department of Biomedical Engineering, Boston University, Boston, Massachusetts.
Abstract:
We relate changes of the airway wall to the response of the intact airway and the whole lung. We address how mechanical conditions and specific structural changes for an airway contribute to hyperresponsiveness resistant to deep inspiration. This review conveys that the origins of hyperresponsiveness do not devolve into an abnormality at single structural level but require examination of the complex interplay of all the parts.
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