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Aorto-ostial atherosclerotic coronary artery disease-Risk factor profiles, demographic & angiographic features

S K Verma1, B Kumar2, V K Bahl1

  • 1Department of cardiology, CTC, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.

International Journal of Cardiology. Heart & Vasculature
|June 16, 2017
PubMed

Insights

Aorto-ostial atherosclerotic coronary artery disease affects 1.5% of patients, predominantly males. Key risk factors include hypercholesterolemia, hypertriglyceridemia, and high TC/HDL ratio, particularly for left main coronary artery involvement.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Atherosclerosis Research

Background:

  • Aorto-ostial atherosclerotic coronary artery disease (A-ASCAD) presents distinct risk factors and patient demographics compared to non-aorto-ostial disease.
  • Understanding these differences is crucial for targeted prevention and treatment strategies in cardiovascular care.

Purpose of the Study:

  • To investigate the etiological factors, including clinical risk factors, demographics, and angiographic features, of A-ASCAD.
  • Specifically focusing on cases involving the left main coronary artery (LMCA), right coronary artery (RCA), or both ostia.

Main Methods:

  • Analysis of 7356 coronary angiograms performed over a two-year period.
  • Detailed evaluation of 95 patients with confirmed A-ASCAD and complete data.

Main Results:

  • A-ASCAD prevalence was 1.5% among all atherosclerotic coronary artery disease patients.
  • Males showed a 5.7-fold higher prevalence than females; isolated ostial LMCA disease was twice as common as isolated ostial RCA disease.
  • Hypertension, diabetes, smoking, hypercholesterolemia (34.7%), hypertriglyceridemia (26.3%), and high TC/HDL ratio (77.9%) were significant risk factors. Hypertriglyceridemia and hypercholesterolemia were independent risk factors for ostial LMCA disease.

Conclusions:

  • Atherosclerotic aorto-ostial disease of coronary arteries has a 1.5% prevalence, with a higher incidence in males.
  • Hypercholesterolemia, hypertriglyceridemia, and elevated TC/HDL ratio are identified as significant risk factors for A-ASCAD.
Abstract

Keywords:
Aorto-ostial diseaseCoronary artery diseaseRisk factors

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