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MMR vaccine in the postpartum does not expose seronegative women to untoward effects
Enrico Finale1, Giuliana Leonardi2, Gaetano Auletta3
1SOC Ostetricia-Ginecologia, Ospedale Castelli, Verbania, Italy.
Background:
The aim of this study was to assess whether rubella vaccination immediately after delivery could expose seronegative women to specific untoward effects.
Methods:
163 rubella-seronegative women received Measles-Mumps-Rubella (MMR) vaccine in the immediate postpartum period; they were evaluated at one month and at three months thereafter through telephone interviews. As controls, we matched 163 rubella-seropositive women, who might experience similar symptoms for any reason in the same timeframe.
Results:
No relevant difference was still observed in the frequency of arthralgia and myalgia at one and three months. Instead, a statistically significant difference in the frequency of cervical lymphadenopathy and cutaneous rash at one month (p = 0.028 and p = 0.005, respectively), was observed between cases and controls. However, no statistical differences were reported at three months for the same symptoms.
Conclusions:
Postpartum rubella vaccination with MMR is safe and advisable to avoid congenital rubella syndrome.
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