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Related Experiment Video

Updated: Feb 28, 2026

Estimating Vestibular Perceptual Thresholds Using a Six-Degree-Of-Freedom Motion Platform
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Estimating Vestibular Perceptual Thresholds Using a Six-Degree-Of-Freedom Motion Platform

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[Persistent postural-perceptual dizziness].

R G Esin1, I Kh Khairullin2, E R Mukhametova2

  • 1Kazan State Medical Academy, Kazan, Russia; Kazan Federal University, Kazan, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|June 16, 2017
PubMed
Summary
This summary is machine-generated.

Anvifen effectively reduced anxiety and improved sleep in patients with persistent postural-perceptual dizziness (PPPD), including those with benign paroxysmal positional vertigo (BPPV) and presbiataxia (PAt). This medication is recommended during vestibular rehabilitation.

Keywords:
aminophenylbutyric acid hydrochlorideanvifenanxietydizzinesspersistent postural perceptual dizziness

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Area of Science:

  • Neurology
  • Otolaryngology
  • Psychiatry

Background:

  • Persistent postural-perceptual dizziness (PPPD) significantly impacts quality of life.
  • Anxiety and sleep disturbances are common comorbidities in PPPD patients.
  • Differential diagnosis of PPPD includes conditions like benign paroxysmal positional vertigo (BPPV) and presbiataxia (PAt).

Purpose of the Study:

  • To investigate the efficacy of anvifen in managing PPPD symptoms.
  • To assess the impact of anvifen on anxiety levels and sleep quality in PPPD patients.
  • To evaluate anvifen's role in patients with co-existing BPPV and PAt.

Main Methods:

  • Eighty-four patients with PPPD were enrolled, categorized by underlying conditions (Meniere's disease, BPPV, ischemic stroke history, PAt).
  • Anxiety was assessed using a 15-point Likert scale questionnaire.
  • Patients received 250 mg of anvifen (aminophenylbutyric acid hydrochloride) three times daily for six weeks.

Main Results:

  • Sleep deprivation was identified as the most frequent trigger for PPPD.
  • The presbiataxia (PAt) group exhibited the highest anxiety levels (19.5±2.89).
  • Anvifen demonstrated significant anxiolytic effects and improved sleep quality across all patient groups.

Conclusions:

  • Anvifen is a beneficial therapeutic option for patients with PPPD.
  • The drug effectively reduces anxiety and enhances sleep quality, aiding vestibular rehabilitation.
  • Anvifen is recommended as a primary treatment for PPPD, especially when combined with cognitive-behavioral therapy.