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Updated: Feb 28, 2026

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Published on: September 28, 2022
Total Synthesis of the Cyclic Dodecapeptides Wewakazole and Wewakazole B
Martyn Inman1, Hannah L Dexter1, Christopher J Moody1
1School of Chemistry, University of Nottingham , University Park, Nottingham NG2 7RD, U.K.
Abstract:
The cyclic dodecapeptides wewakazole and wewakazole B have been synthesized by a divergent strategy via a common tris-proline containing oxazole octapeptide and two separate bis-oxazole containing tetrapeptide units, followed by peptide coupling and macrocyclization. The three oxazole amino acid fragments are readily accessible by rhodium(II)-catalyzed amide N-H insertion of diazocarbonyl compounds, or by the cycloaddition of rhodium carbenoids with nitriles.
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