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Related Experiment Video

Updated: Feb 28, 2026

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

The Making of a Pathogen.

Kim Lewis¹, Mariaelena Caboni¹

¹Antimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA 02115, USA.

Cell Host & Microbe

|June 16, 2017

Summary

This summary is machine-generated.

Enterococci are resilient opportunistic pathogens. Their traits for surviving hospital environments, including resistance to antibiotics and disinfectants, originated from adaptations to terrestrial life millions of years ago.

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Area of Science:

Microbiology
Evolutionary Biology
Pathogen Research

Background:

Enterococci are opportunistic pathogens known for their remarkable resistance.
This resistance extends to antibiotics, disinfectants, and desiccation, making them difficult to eradicate.
Understanding the evolutionary origins of these traits is crucial for infection control.

Purpose of the Study:

To investigate the evolutionary history of Enterococci.
To determine when and how traits promoting survival in hospital settings were acquired.
To link the adaptation of Enterococci to terrestrial environments with their pathogenic capabilities.

Main Methods:

Phylogenetic analysis of Enterococci.
Comparative genomics to identify key survival traits.
Reconstruction of evolutionary events and environmental adaptations.

Main Results:

Enterococci diverged from marine ancestors approximately 400 million years ago.
Traits essential for survival in terrestrial and hospital environments were acquired during this early adaptation phase.
These ancient adaptations contribute to the current robustness and resistance of Enterococci.

Conclusions:

The extraordinary resistance of Enterococci is rooted in ancient evolutionary adaptations to terrestrial life.
Understanding this evolutionary trajectory provides insights into their persistence as hospital pathogens.
This knowledge can inform novel strategies for combating Enterococcus infections.