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Related Experiment Video

Updated: Feb 28, 2026

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Video head impulse test can detect brainstem dysfunction in multiple sclerosis.

Ivan Pavlović1, Berislav Ruška1, Tin Pavičić1

  • 1University Hospital Center Zagreb, Department of Neurology, Referral Center for Autonomic Nervous System Disorders, Zagreb, Croatia.

Multiple Sclerosis and Related Disorders
|June 17, 2017
PubMed
Summary

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This summary is machine-generated.

The video head impulse test (vHIT) can identify brainstem dysfunction in multiple sclerosis (MS) patients. This diagnostic tool shows significant differences in vHIT results between MS patients and healthy controls, correlating with brainstem lesions.

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Neurology

Background:

  • Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system.
  • Brainstem lesions are common in MS and can lead to various neurological deficits.
  • The video head impulse test (vHIT) assesses vestibulo-ocular reflex function.

Purpose of the Study:

  • To evaluate the utility of vHIT in detecting brainstem lesions in MS patients.
  • To compare vHIT findings between MS patients and healthy controls.
  • To determine the association between vHIT abnormalities and MRI-confirmed brainstem lesions in MS.

Main Methods:

  • Sixty-eight participants (29 MS patients, 39 healthy controls) underwent vHIT.
  • vHIT pathology was defined by specific criteria for saccades and canal gains.
Keywords:
Multiple sclerosisVestibulo-ocular reflexVideo head impulse test

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  • Brainstem lesions were assessed using MRI in the MS group.

    • Main Results:

    • MS patients exhibited significantly more vHIT abnormalities (38%) compared to healthy controls (11%).
    • Reduced lateral canal gain and increased saccade frequency were observed in MS patients.
    • A significant association was found between brainstem MRI lesions and bilateral vHIT pathology in the lateral semicircular canal.

    Conclusions:

    • vHIT is a sensitive tool for detecting brainstem dysfunction in MS patients.
    • vHIT findings correlate with the presence of brainstem lesions in MS.
    • vHIT can aid in the diagnosis and monitoring of MS-related neurological deficits.