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Related Experiment Videos

Decrease in beta-receptor density explaining the development of pindolol- and prenalterol-tolerance in orthostatic

E B Andersen, H O Lindskov, J Marving

    Danish Medical Bulletin
    |June 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

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    Tolerance to prenalterol, a beta-blocker, developed in a patient with diabetic autonomic dysfunction. This was linked to a decrease in beta-adrenergic receptor density, impacting orthostatic hypotension treatment.

    Area of Science:

    • Cardiology
    • Pharmacology
    • Endocrinology

    Background:

    • Diabetic autonomic dysfunction can cause orthostatic hypotension.
    • Pindolol initially managed symptoms but efficacy waned.
    • Beta-adrenergic receptor function is crucial for cardiovascular regulation.

    Observation:

    • A patient with diabetic autonomic dysfunction experienced symptom recurrence despite pindolol.
    • Prenalterol, a beta-blocker with intrinsic sympathomimetic activity, initially improved orthostatic hypotension.
    • Hemodynamic improvements (stroke volume, LVEDV) were observed during tilt testing after short-term prenalterol use.

    Findings:

    • Continued prenalterol treatment led to symptom and hemodynamic recurrence.
    • Lymphocyte beta-receptor density decreased to subnormal levels correlating with loss of clinical effect.

    Related Experiment Videos

  • Tolerance to prenalterol was associated with reduced beta-adrenergic receptor density.

    • Implications:

    • Beta-receptor downregulation may explain tolerance development to prenalterol.
    • Understanding receptor dynamics is key for managing autonomic dysfunction.
    • This case highlights the complex interplay between beta-blockers, receptor density, and treatment efficacy.