Related Experiment Video
Updated: Feb 28, 2026
06:57
Effects of Surgical Masks on Cardiopulmonary Function in Healthy Subjects
Published on: February 12, 2021
3.7K
Does sildenafil improve ventilatory function in asthmatic subjects?
Mukhallad Aljanabi1, Said Khatib1, Nayef S Gharaibeh1
1Dept of Physiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Breathe (Sheffield, England)
|June 17, 2017
Summary
Sildenafil, commonly used for erectile dysfunction, was investigated for its potential to treat asthma. Research suggests it may offer benefits for managing asthma symptoms.
Area of Science:
- Pulmonary Medicine
- Pharmacology
Background:
- Asthma is a chronic respiratory disease characterized by airway inflammation and bronchoconstriction.
- Current asthma treatments primarily focus on bronchodilators and anti-inflammatory agents.
- There is an ongoing need for novel therapeutic strategies to improve asthma control.
Purpose of the Study:
- To evaluate the efficacy and safety of sildenafil in patients with asthma.
- To explore the potential mechanisms by which sildenafil might affect airway function.
Main Methods:
- A review of existing studies and clinical trials investigating sildenafil's effects on asthma parameters.
- Analysis of data related to lung function, symptom scores, and adverse events.
Main Results:
- Sildenafil demonstrated a potential to improve bronchodilation and reduce airway hyperresponsiveness in some asthma patients.
- Observed benefits were associated with phosphodiesterase type 5 (PDE5) inhibition, a known mechanism of sildenafil.
Conclusions:
- Sildenafil shows promise as an adjunctive therapy for asthma, particularly in specific patient subgroups.
- Further large-scale clinical trials are warranted to confirm its therapeutic role and optimal dosage in asthma management.
More Related Videos
Related Concept Videos
01:19Factors Affecting Pulmonary Ventilation
3.4K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
3.4K
01:28Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
663
Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
663
01:25Antiasthma Drugs: β2-Adrenoceptor Agonists
1.9K
Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
1.9K
01:24Asthma-III: Symptoms and Complications
3.4K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
3.4K
01:30Asthma-IV: Diagnostic and Management
3.2K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.2K
01:24Antiasthma Drugs: Methylxanthines
1.8K
Theophylline, a member of the methylxanthine class of bronchodilators, has long been used in asthma management. While its exact mechanism of action is not fully understood, it is believed to have multiple effects on various cellular processes.
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
1.8K