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Systematic Review and Meta-analysis of Prevalence of Coronary Artery Disease in Adult Patients with Cardiac Myxomas

Matheus Silva1, Matheus Carneiro2, Júlio Nunes2

  • 1Inteventional Cardiology Department, Hospital Universitário Ciências Médicas, Belo Horizonte, 30140-073, Brazil.

F1000Research
|June 17, 2017
PubMed

Insights

Coronary artery disease (CAD) affects 20.7% of cardiac myxoma patients. Further research is needed to determine if routine coronary angiography is necessary before surgery.

Area of Science:

  • Cardiology
  • Cardiovascular Surgery

Background:

  • Prevalence estimates of coronary artery disease (CAD) in cardiac myxoma patients vary.
  • Cardiac myxomas are primary heart tumors, with atrial myxomas being the most common type.

Purpose of the Study:

  • To systematically review and meta-analyze observational studies.
  • To summarize the point prevalence of CAD in adults with cardiac myxomas.

Main Methods:

  • Systematic literature search of MEDLINE and LILACS databases.
  • Inclusion of 6 observational studies.
  • Pooled prevalence estimation using a random-effects model.

Main Results:

  • The pooled prevalence of CAD in adult cardiac myxoma patients was 20.7%.
  • Low heterogeneity was observed (I² = 14.86%).
  • Publication bias was assessed using Egger's test and the Trim and Fill method.

Conclusions:

  • The necessity of routine preoperative coronary angiography in cardiac myxoma patients remains debated.
  • Coronary disease and neovascularity may influence surgical management.
  • Further studies are required to definitively answer this clinical question.

Keywords:
Systematic reviewcoronary angiographycoronary artery diseasemeta-analysismyxoma

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