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Related Experiment Video

Updated: Feb 28, 2026

Imaging Molecular Adhesion in Cell Rolling by Adhesion Footprint Assay
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Imaging Molecular Adhesion in Cell Rolling by Adhesion Footprint Assay

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Model of Cell Crawling Controlled by Mechanosensitive Adhesion.

M Leoni1, P Sens1

  • 1Institut Curie, PSL Research University, CNRS, UMR 168, 26 rue d'Ulm, F-75005 Paris, France.

Physical Review Letters
|June 17, 2017
PubMed
Summary

Cellular crawling depends on how molecular bonds attach and detach. Optimal movement occurs with specific binding rates, and directed motion requires mechanosensitive linkers like slip or catch bonds.

Area of Science:

  • Biophysics
  • Cellular mechanics
  • Soft matter physics

Background:

  • Cells and biomimetic objects move by exerting traction forces on substrates.
  • Adhesive linkers mediate cell-substrate interactions through stochastic binding and unbinding.

Purpose of the Study:

  • To investigate the role of adhesion kinetics and mechanosensitivity in cell motility.
  • To determine how varying binding and unbinding rates affect cell translocation.
  • To analyze directed motion based on different linker properties (slip vs. catch bonds).

Main Methods:

  • Modeling of model cells and biomimetic soft objects.
  • Analysis of traction forces generated by molecular complexes.
  • Stochastic modeling of linker binding and unbinding dynamics.

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  • Investigation of force dipole diffusion coefficients.

    • Main Results:

    • Diffusion coefficient for a force dipole is maximized at a specific unbinding-to-binding rate ratio.
    • Directed cell motion requires mechanosensitive linkers (slip or catch bonds).
    • Catch bonds yield higher average migration speeds but also increased fluctuations compared to slip bonds.

    Conclusions:

    • Adhesion kinetics significantly influence cell translocation dynamics.
    • Mechanosensitivity of cell-substrate linkers is crucial for directed cell migration.
    • The balance between speed and fluctuations in migration depends on the type of mechanosensitive bond (slip vs. catch).