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Updated: Feb 28, 2026
07:58
Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates
Published on: May 30, 2017
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Vaxchora: A Single-Dose Oral Cholera Vaccine.
Adriana Cabrera1, Jayne E Lepage1, Karyn M Sullivan1
11 MCPHS University, Worcester, MA, USA.
The Annals of Pharmacotherapy
|June 18, 2017
Summary
Vaxchora is an FDA-approved, single-dose oral cholera vaccine offering 90.3% protection. It is safe and effective for US adult travelers to cholera-affected areas, with mild side effects.
Area of Science:
- Vaccinology
- Infectious Diseases
- Travel Medicine
Background:
- Cholera remains a significant public health concern, particularly in travel-related contexts.
- The development of effective and convenient cholera vaccines is crucial for disease prevention.
Purpose of the Study:
- To review clinical trials evaluating the efficacy and safety of Vaxchora (CVD 103-HgR).
- To assess Vaxchora's suitability as a single-dose oral vaccine for preventing travel-related cholera.
Main Methods:
- Comprehensive literature search of MEDLINE and EMBASE databases.
- Inclusion of human clinical trials published in English since 2010.
- Utilized ClinicalTrials.gov for unpublished data and bibliographic review.
Main Results:
- Vaxchora demonstrated 90.3% efficacy in human trials with V cholerae challenge.
- Immunogenicity studies showed 90% systemic vibriocidal antibody conversion at 6 months.
- The vaccine was generally well-tolerated, with common side effects including fatigue, headache, and abdominal pain.
Conclusions:
- Vaxchora is the sole FDA-approved single-dose oral cholera vaccine for US adult travelers.
- Efficacy and safety are not established for children, immunocompromised individuals, pregnant/breastfeeding women, or residents of endemic areas.
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