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Related Concept Videos

Infertility in Males01:23

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
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High-Intensity Exercise Training for Improving Reproductive Function in Infertile Patients: A Randomized Controlled

Behzad Hajizadeh Maleki1, Bakhtyar Tartibian2

  • 1Department of Sports Medicine, Justus-Liebig-University, Giessen, Germany.

Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'Obstetrique Et Gynecologie Du Canada : JOGC
|June 20, 2017
PubMed
Summary

High-intensity exercise significantly improved male reproductive function by reducing inflammation and oxidative stress. This program enhanced semen quality and pregnancy rates in infertile men.

Keywords:
High-intensity exercise trainingcytokinesmale factor infertilityrandomized controlled trialredox status

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Area of Science:

  • Reproductive Medicine
  • Exercise Physiology
  • Male Infertility

Background:

  • Male factor infertility affects a significant portion of couples seeking fertility treatment.
  • Inflammation and oxidative stress are implicated as key contributors to male infertility.
  • Lifestyle interventions are increasingly explored to improve male reproductive health.

Purpose of the Study:

  • To evaluate the efficacy of a 24-week high-intensity exercise program on male reproductive function.
  • To assess the impact of exercise on inflammatory and oxidative stress markers in infertile men.
  • To determine the effect of exercise on semen quality, sperm DNA integrity, and pregnancy rates.

Main Methods:

  • A randomized controlled trial involving 433 infertile men.
  • Participants were assigned to either a high-intensity exercise group or a non-exercise control group.
  • Measurements included seminal inflammatory biomarkers, oxidative stress markers, semen parameters, sperm DNA fragmentation, and pregnancy rates.

Main Results:

  • The exercise group showed significant reductions in inflammatory biomarkers (IL-6, TNF-α) and oxidative stress markers (ROS, MDA).
  • Significant improvements were observed in semen quality parameters and sperm DNA integrity in the exercise group.
  • The pregnancy rate was also favorably improved in men participating in the exercise program.

Conclusions:

  • A 24-week high-intensity exercise program is beneficial for improving male reproductive function.
  • Exercise effectively reduces inflammation and oxidative stress, leading to better semen quality and fertility outcomes.
  • High-intensity exercise can be recommended as an adjunct therapy for male factor infertility.