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Updated: Feb 28, 2026

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats
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Saccharin Aza Bioisosteres-Synthesis and Preclinical Property Comparisons

Yantao Chen1, Carl-Johan Aurell2, Anna Pettersen3

  • 1Medicinal Chemistry, Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development, AstraZeneca R&D Gothenburg, 431 83 Mölndal, Sweden.

ACS Medicinal Chemistry Letters
|June 20, 2017
PubMed

Keywords:
ChemoselectivityChlorinating reagentFunctionalizationMedicinal chemistryN-SubstitutionPseudosaccharinRegioselectivityRing-closureSulfonamideSulfonimidamideTelescoping synthesis

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