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Microfluidic Applications for Disposable Diagnostics
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Turning the Page: Advancing Paper-Based Microfluidics for Broad Diagnostic Application.

Max M Gong1,2, David Sinton1

  • 1Department of Mechanical and Industrial Engineering, University of Toronto , 5 King's College Road, Toronto, Ontario, Canada M5S 3G8.

Chemical Reviews
|June 20, 2017
PubMed
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Paper-based microfluidic diagnostics offer a low-cost solution for infectious disease diagnosis, improving global health accessibility. Advances include controlled fluid transport, nucleic acid analysis, and smartphone integration, with emerging applications in fertility and wearables.

Area of Science:

  • Biomedical Engineering
  • Global Health Diagnostics
  • Microfluidics

Background:

  • Infectious diseases pose a significant global health challenge, necessitating accessible diagnostic tools.
  • Paper-based microfluidic diagnostics emerged in 2007 as a low-cost alternative to traditional laboratory testing.
  • The primary goal is to enhance medical diagnostic accessibility, particularly in developing nations.

Purpose of the Study:

  • To review advancements in paper-based microfluidic diagnostics for medical diagnosis between 2007 and 2016.
  • To analyze the evolution of fluid and analyte transport control in paper-based assays.
  • To highlight key developments in sample processing, analysis, and emerging applications.

Main Methods:

  • Review of scientific literature on paper-based microfluidic diagnostics from 2007-2016.

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  • Analysis of fluid transport theories and control strategies in paper substrates.
  • Examination of advancements in sample processing, nucleic acid analysis, and smartphone-based detection.

    • Main Results:

    • Development of strategies for controlled fluid and analyte transport, enabling complex assays.
    • Successful translation of nucleic acid analysis to paper-based platforms.
    • Emergence of smartphone-based analysis and novel applications like fertility testing and wearable diagnostics.

    Conclusions:

    • Paper-based microfluidic diagnostics have shown significant progress, offering laboratory-comparable analytical capabilities.
    • These technologies hold immense potential for improving global health through accessible diagnostics.
    • Future work should address remaining challenges and capitalize on emerging opportunities for wider dissemination.