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Development of emotional and behavioral problems in neurofibromatosis type 1 during young childhood

André B Rietman1, Rianne Oostenbrink2, Kimberley van Noort1

  • 1Department of Pediatric Neurology, Erasmus MC-Sophia Children's Hospital and ENCORE Expertise Centre for Neurodevelopmental Disorders, Rotterdam, The Netherlands.

American Journal of Medical Genetics. Part A
|June 20, 2017
PubMed

Insights

Early internalizing problems in children with neurofibromatosis type 1 (NF1) predict later behavioral issues. Identifying these early behavioral problems is crucial for intervention in NF1 patients.

Area of Science:

  • Pediatric Neurology
  • Developmental Psychology
  • Genetics

Background:

  • Neurofibromatosis type 1 (NF1) is a genetic disorder associated with various developmental challenges.
  • Early identification of behavioral issues in children with NF1 is essential for timely intervention.
  • Longitudinal studies are needed to understand the developmental trajectory of behavioral problems in NF1.

Purpose of the Study:

  • To investigate the association between early behavioral, intellectual, and language development and later behavioral problems in young children with NF1.
  • To determine if preschool-age behavioral issues predict school-age behavioral problems in NF1.
  • To analyze the developmental course of internalizing problems in children with NF1.

Main Methods:

  • Retrospective longitudinal study design.
  • Involved two assessments: preschool age and school age.
  • Utilized multivariable linear regression to analyze associations between baseline and secondary assessments.

Main Results:

  • Intelligence and language development were not associated with internalizing problems.
  • Parent-rated internalizing behavioral problems significantly increased with age.
  • Preschool-age internalizing problems predicted later internalizing problems (adjusted R² = 0.33, p = 0.003).

Conclusions:

  • Early internalizing behavioral problems in preschool-aged children with NF1 are predictive of later internalizing problems.
  • Behavioral assessments in early childhood are critical for identifying children with NF1 at risk for persistent behavioral issues.
  • Further research should focus on interventions targeting early behavioral problems in NF1.

Keywords:
emotional and behavioral problemsintelligenceinternalizing problemslanguagelongitudinalneurofibromatosis type 1

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